ITI Research Group



Supported by:
Bioinformatics Applications for microorganisms analyses

The bioinformatics Applications for microorganisms analyses project is focused on performing computational analysis of mutations of hepatitis C virus (HCV) associated with resistance to direct-acting antiviral (DAA). Chronic HCV infection remains a serious public health problem worldwide, affecting 200 million people and causing about 10,000 deaths annually. It is therefore important to determine the variability of the HCV NS3, NS5A and NS5B genes, the target of DAA, to determine their potential impact on new DAA therapy in patients infected with HCV, to prevent potential therapeutic failures and to optimize future treatment regimens choosing the most appropriate DAA for each patient.

  • Start Date: 2013-01-01
  • Authors
    • Hector Florez
    • Karina Salvatierra
  • Software
    • PSSA
    • BMA
  • Publications

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        • Journal Papers
          1. Sweta Singh, Hector Florez. Coronavirus disease 2019 drug discovery through molecular docking. F1000 Research. ISSN:2046-1402. vol:9(502). p:1-9. (2020).
          2. Hector Florez, Sweta Singh. Online dashboard and data analysis approach for assessing COVID-19 case and death data. F1000 Research. ISSN:2046-1402. vol:9(570). p:1-9. (2020).
          3. Karina Salvatierra, Marcos Vera, Hector Florez. Bioinformatics Methods to Discover Antivirals Against Zika Virus. Communications in Computer and Information Science. ISSN:1865-0929. vol:1051. p:3-14. (2019).
          4. . . . ISSN:. vol:. p:. ().
          5. . . . ISSN:. vol:. p:. ().
          6. Karina Salvatierra, Hector Florez . Bioinformatics Approach to Analyze Influenza Viruses. Communications in Computer and Information Science. ISSN:1865-0929. vol:916. p:442-452. (2018).
          7. Mauro Guardiola, Karina Salvatierra, Hector Florez. Computer analysis of resistance mutations to HCV NS5A antivirals. International Journal of Infectious Diseases. ISSN:1201-9712. vol:73S. p:382-383. (2018).
          8. Karina Salvatierra, Hector Florez. Computational analysis of resistance mutations in the hepatitis C virus. Vínculos. ISSN:1794-211X. vol:15. p:27-33. (2018).
          9. Florez Hector, Salvatierra Karina. A Web-Based Approach for Analyzing Microorganism Sequences. Communications in Computer and Information Science. ISSN:1865-0929. vol:742. p:96-107. (2017).
          10. . . . ISSN:. vol:. p:. ().
          11. Florez Hector, Salvatierra Karina. Bioinformatics Study of Mutations of Resistance to Antivirals in the NS5A Gen of HCV. Information. ISSN:1343-4500. vol:20 (9A). p:6665-6672. (2017).
          12. . . . ISSN:. vol:. p:. ().
          13. . . . ISSN:. vol:. p:. ().
          14. Karina Salvatierra, Hector Florez. Pathogen Sequence Signature Analysis (PSSA): A software tool for analyzing sequences to identify microorganism genotypes. F1000 Research. ISSN:2046-1402. vol:6 (21). p:1-8. (2017).
          15. Karina Salvatierra, Hector Florez. Prevalence of hepatitis B and C infections in hemodialysis patients. F1000 Research. ISSN:2046-1402. vol:5 (1910). p:1-6. (2016).
          16. Karina Salvatierra, Hector Florez. Biomedical Mutation Analysis (BMA): A software tool for analyzing mutations associated with antiviral resistance. F1000 Research. ISSN:2046-1402. vol:5 (1141). p:1-9. (2016).
          17. . . . ISSN:. vol:. p:. ().
          18. . . . ISSN:. vol:. p:. ().
          19. Karina Salvatierra, Hector Florez. Análisis del Virus de la Hepatitis C en pacientes en hemodiálisis. Infectio. ISSN:0123-9392. vol:20 (3). p:130-137. (2015).
          20. . . . ISSN:. vol:. p:. ().
          21. Karina Salvatierra, Hector Florez. Análisis Computacional de Mutaciones de Resistencias a Inhibidores de la Proteasa NS3 Y Polimerasa NS5B del Virus de la Hepatitis C. Biomédica. ISSN:0120-4157. vol:35. p:125. (2015).
        • Academic Conferences
          1. Karina Salvatierra, Marcos Vera, Hector Florez. Bioinformatics Methods to Discover Antivirals Against Zika Virus. p:3-14. Madrid, Spain. (2019).
          2. . . . ().
          3. . . . ().
          4. Karina Salvatierra, Hector Florez . Bioinformatics Approach to Analyze Influenza Viruses. p:442-452. Medellin, Colombia. (2018).
          5. Florez Hector, Salvatierra Karina. A Web-Based Approach for Analyzing Microorganism Sequences. p:96-107. Cartagena, Colombia. (2017).
          6. . . . ().
          7. . . . ().
          8. . . . ().
          9. Hector Florez, Karina Salvatierra. A Tool for Analyzing Mutations in Biomedical Microorganisms. p:25-33. Orlando, United States. (2017).
          10. . . . ().
          11. . . . ().
          12. . . . ().

        Solutions design in the context of model driven engineering

        Through the creation of metamodels and model to model and model-to-text transformations, it is desirable to create software projects almost automatically, from the creation of a single conceptual model.

        • Start Date: 2013-01-01
        • Authors
          • Hector Florez
          • Daniel Sanchez
          • Oscar Mendez
        • Software
          • CFP
          • RIS
          • DevPHP
          • RIWA
          • PHPGen
        • Publications
          • Books
            1. Hector Florez. Sistemas Digitales. Ediciones de la U. ISSN:978-958-762-190-7. 2014.
          • Book Chapters
            1. Hector Florez. Human Factors in Automated Analysis for Enterprise Models. IGI Global. ISSN:180619075135. 2019.
            2. Hector Florez, Mario Sanchez, Jorge Villalobos. Drafting Enterprise Models. IGI Global. ISSN:9781522555223. 2019.

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          • Journal Papers
            1. Hector Florez, Edwarth Garcia, Deisy Muñoz . Automatic Code Generation System for Transactional Web Applications. Lecture Notes in Computer Science. ISSN:0302-9743. vol:11623. p:436-451. (2019).
            2. Hector Florez, Marcelo Leon. Model Driven Engineering Approach to Configure Software Reusable Components. Communications in Computer and Information Science. ISSN:1865-0929. vol:942. p:352-363. (2018).
            3. Daniel Sanchez, Hector Florez. Model Driven Engineering Approach to Manage Peripherals in Mobile Devices. Lecture Notes in Computer Science. ISSN:0302-9743. vol:10963. p:353-364. (2018).
            4. Daniel Sanchez, Oscar Mendez, Hector Florez . An Approach of a Framework to Create Web Applications. Lecture Notes in Computer Science. ISSN:0302-9743. vol:10963. p:341-352. (2018).
            5. Hector Florez, Mario Sanchez, Jorge Villalobos. Analysis of Imprecise Enterprise Models. Lecture Notes in Business Information Processing. ISSN:1865-1348. vol:248. p:349-364. (2016).
            6. Hector Florez, Mario Sanchez, Jorge Villalobos. A Catalog of Automated Analysis Methods for Enterprise Models. SpringerPlus. ISSN:2193-1801. vol:5 (406). p:1-24. (2016).
            7. Hector Florez. Metamodels composition strategy for the model driven engineering context. Tecnura. ISSN:0123-921X. vol:44. p:109-120. (2015).
            8. Paola Gómez, Mario Sánchez, Hector Florez, Jorge Villalobos. An Approach to the Co-creation of Models and Metamodels in Enterprise Architecture Projects. Journal of Object Technology. ISSN:1660-1769. vol:13 (3). p:1-29. (2014).
            9. Hector Florez, Mario Sanchez, Jorge Villalobos. Embracing Imperfection in Enterprise Architecture Models. CEUR Workshops Proceedings. ISSN:1613-0073. vol:1023. p:8-17. (2013).
            10. Hector Florez. Adapting models in metamodels composition processes. Vínculos. ISSN:1794-211X. vol:10 (1). p:96-108. (2013).
            11. . . . ISSN:. vol:. p:. ().
          • Academic Conferences
            1. Hector Florez, Edwarth Garcia, Deisy Muñoz . Automatic Code Generation System for Transactional Web Applications. p:436-451. Saint Petesburg, Russia. (2019).
            2. Hector Florez, Marcelo Leon. Model Driven Engineering Approach to Configure Software Reusable Components. p:352-363. Bogota, Colombia. (2018).
            3. Daniel Sanchez, Hector Florez. Model Driven Engineering Approach to Manage Peripherals in Mobile Devices. p:353-364. Melbourne, Australia. (2018).
            4. Daniel Sanchez, Oscar Mendez, Hector Florez . An Approach of a Framework to Create Web Applications. p:341-352. Melbourne, Australia. (2018).
            5. Daniel Sanchez, Oscar Mendez, Hector Florez . Applying the 3-layer Model in the Construction of a Framework to Create Web Applications. p:364-369. Orlando, United States. (2017).
            6. Hector Florez, Mario Sanchez, Jorge Villalobos. Analysis of Imprecise Enterprise Models. p:349-364. Ljubljana, Slovenia. (2016).
            7. Hector Florez, Mario Sanchez, Jorge Villalobos. Extensible Model-based Approach for Supporting Automatic Enterprise Analysis. p:32-41. Ulm, Germany. (2014).
            8. Hector Florez, Mario Sanchez, Jorge Villalobos. iArchiMate: A Tool for Managing Imperfection in Enterprise Models. p:201-210. Ulm, Germany. (2014).
            9. Hector Florez, Mario Sanchez, Jorge Villalobos. Supporting Drafts for Enterprise Modeling. p:200-206. Pereira, Colombia. (2014).
            10. Hector Florez, Mario Sanchez, Jorge Villalobos. Embracing Imperfection in Enterprise Architecture Models. p:8-17. Riga, Latvia. (2013).
            11. . . . ().

          Mobile applications in business contexts

          By creating mobile business applications, specific business solutions are created. Furthermore, such applications contribute to the generation of new enterprises

          • Start Date: 2014-01-01
          • Authors
            • Hector Florez
            • Daniel Sanchez
          • Software
            • Black Jack
            • ARtesanias App
            • TelApp
            • BlackJack App
          • Publications

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                • Journal Papers
                  1. Luis Wanumen, Hector Florez. Architectural Approaches for Phonemes Recognition Systems. Communications in Computer and Information Science. ISSN:1865-0929. vol:942. p:267-279. (2018).
                  2. Daniel Sanchez, Hector Florez. Model Driven Engineering Approach to Manage Peripherals in Mobile Devices. Lecture Notes in Computer Science. ISSN:0302-9743. vol:10963. p:353-364. (2018).
                  3. . . . ISSN:. vol:. p:. ().
                  4. . . . ISSN:. vol:. p:. ().
                  5. . . . ISSN:. vol:. p:. ().
                  6. . . . ISSN:. vol:. p:. ().
                • Academic Conferences
                  1. Luis Wanumen, Hector Florez. Architectural Approaches for Phonemes Recognition Systems. p:267-279. Bogota, Colombia. (2018).
                  2. Daniel Sanchez, Hector Florez. Model Driven Engineering Approach to Manage Peripherals in Mobile Devices. p:353-364. Melbourne, Australia. (2018).
                  3. . . . ().
                  4. . . . ().
                  5. . . . ().
                  6. . . . ().


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