The bioinformatics Applications for microorganisms analyses project is focused on performing computational analysis of mutations of hepatitis C virus (HCV) associated with resistance to direct-acting antiviral (DAA). Chronic HCV infection remains a serious public health problem worldwide, affecting 200 million people and causing about 10,000 deaths annually. It is therefore important to determine the variability of the HCV NS3, NS5A and NS5B genes, the target of DAA, to determine their potential impact on new DAA therapy in patients infected with HCV, to prevent potential therapeutic failures and to optimize future treatment regimens choosing the most appropriate DAA for each patient.
- Start Date: 2013-01-01
- Authors
- Hector Florez
- Karina Salvatierra
- Software
- Publications
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- Journal Papers
- Sweta Singh, Hector Florez. Coronavirus disease 2019 drug discovery through molecular docking. F1000 Research. ISSN:2046-1402. vol:9(502). p:1-9. (2020).
- Hector Florez, Sweta Singh. Online dashboard and data analysis approach for assessing COVID-19 case and death data. F1000 Research. ISSN:2046-1402. vol:9(570). p:1-9. (2020).
- Karina Salvatierra, Marcos Vera, Hector Florez. Bioinformatics Methods to Discover Antivirals Against Zika Virus. Communications in Computer and Information Science. ISSN:1865-0929. vol:1051. p:3-14. (2019).
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- Karina Salvatierra, Hector Florez . Bioinformatics Approach to Analyze Influenza Viruses. Communications in Computer and Information Science. ISSN:1865-0929. vol:916. p:442-452. (2018).
- Mauro Guardiola, Karina Salvatierra, Hector Florez. Computer analysis of resistance mutations to HCV NS5A antivirals. International Journal of Infectious Diseases. ISSN:1201-9712. vol:73S. p:382-383. (2018).
- Karina Salvatierra, Hector Florez. Computational analysis of resistance mutations in the hepatitis C virus. Vínculos. ISSN:1794-211X. vol:15. p:27-33. (2018).
- Florez Hector, Salvatierra Karina. A Web-Based Approach for Analyzing Microorganism Sequences. Communications in Computer and Information Science. ISSN:1865-0929. vol:742. p:96-107. (2017).
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- Florez Hector, Salvatierra Karina. Bioinformatics Study of Mutations of Resistance to Antivirals in the NS5A Gen of HCV. Information. ISSN:1343-4500. vol:20 (9A). p:6665-6672. (2017).
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- Karina Salvatierra, Hector Florez. Pathogen Sequence Signature Analysis (PSSA): A software tool for analyzing sequences to identify microorganism genotypes. F1000 Research. ISSN:2046-1402. vol:6 (21). p:1-8. (2017).
- Karina Salvatierra, Hector Florez. Prevalence of hepatitis B and C infections in hemodialysis patients. F1000 Research. ISSN:2046-1402. vol:5 (1910). p:1-6. (2016).
- Karina Salvatierra, Hector Florez. Biomedical Mutation Analysis (BMA): A software tool for analyzing mutations associated with antiviral resistance. F1000 Research. ISSN:2046-1402. vol:5 (1141). p:1-9. (2016).
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- Karina Salvatierra, Hector Florez. Análisis del Virus de la Hepatitis C en pacientes en hemodiálisis. Infectio. ISSN:0123-9392. vol:20 (3). p:130-137. (2015).
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- Karina Salvatierra, Hector Florez. Análisis Computacional de Mutaciones de Resistencias a Inhibidores de la Proteasa NS3 Y Polimerasa NS5B del Virus de la Hepatitis C. Biomédica. ISSN:0120-4157. vol:35. p:125. (2015).
- Academic Conferences
- Karina Salvatierra, Marcos Vera, Hector Florez. Bioinformatics Methods to Discover Antivirals Against Zika Virus. p:3-14. Madrid, Spain. (2019).
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- Karina Salvatierra, Hector Florez . Bioinformatics Approach to Analyze Influenza Viruses. p:442-452. Medellin, Colombia. (2018).
- Florez Hector, Salvatierra Karina. A Web-Based Approach for Analyzing Microorganism Sequences. p:96-107. Cartagena, Colombia. (2017).
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- Hector Florez, Karina Salvatierra. A Tool for Analyzing Mutations in Biomedical Microorganisms. p:25-33. Orlando, United States. (2017).
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